Abstract:A new type elderly milk was made by adding vitamin B1, vitamin B5, DHA, and choline, which could prevent Alzheimer. Different influencing factors were investigated through single factor tests and the optimized formula was obtained through the orthogonal experiments. The results indicated the optimal formula was:1.7mg/kg vitamin B1,1mg/kg vitamin B5,0mg/kg DHA, and 700mg/kg choline. In the product, the viable contents of vitamin B1, vitamin B5, DHA, and choline were 1.04,8.6,3, and 547mg/kg, respectively, which was benefit to brain health.