Abstract:The deformation process of food in oral processing and the relationship between oral processing ability and the formation of swallowable pellets had aroused extensive attention. However, it was difficult to directly observe the food oral processing of testers, obtain the relevant data of chewing experiment, and to repeatedly quantify the oral processing ability, which made it difficult to measure the chewing efficiency. In order to solve these problems, based on the oral simulation platform developed in the early stage, paraffin and peanuts were used as test samples to carry out chewing experiments through oral simulation platform and testers, respectively, and the mastication efficiency index of collected pellets were analyzed and compared for. Data analysis showed that there was a significant correlation between in vivo and in vitro chewing tests and chewing times, and there were significant differences in peanut d50 and paraffin masticatory efficiency index MEI between in vivo and in vitro groups under different chewing times (P<0.05). When the chewing times reached the number of times required for swallowing, the masticatory efficiency indexes of the obtained pellets in vitro and the samples collected from the oral cavity of the testers had high consistency. Based on the oral simulation platform, which could simulate human food oral processing and produce food pellets, food chewing experiments were carried out to determine the chewing efficiency, in order to effectively replace the experimental personnel, reduce the experimental cost and increase the repeatability of the experiment.